The Callisto Protocol: The Callisto Protocol 100% Video Guide

Welcome to my guide

If you look for something specific use your browser search engine (Ctrl+F)

Be sure to rate my work to help me reach more people

Guide icon credit: Pooterman https://www.deviantart.com/pooterman

Minimum number of playthroughs:
1 – Normal run on any difficulty (collectibles and achievements)
2 – New Game + run on Maximum Security (Hard Difficulty)
2.5 – upgrade all items (I did it in chapter 5 so it’s about hal a run)
3 – Hardcore Mode Run
4 – New Game + on Hardcore Mode
5 – Contagion Mode Run
6 – Final Transmission DLC
7 – Riot Mode with 50 waves

Yeah, that quite a bit of playing so let’s start.

1
Play the game on any difficulty you like. I would recommend minimum or normal security, Leave Maximum Security for NG+ when you will have all equipment from previous run, extra inventory slots plus you will know what to expect and how to fight bosses.

During your first playthrough get all implant bios for Grim Reaper and do all other achievements.
Below you will find compleat all collectibles videos for each chapter with added achievements so you won’t miss anything.
If you pick up implant bio and die before checkpoint you will have to pick it up again after load.
There are also some grinding achievements like killing 10 enemies with environment so be aware of that.

2 and 2.5
Replay main game in NG+. You have to finish it once on Maximum Security for The Protocol is About Life achievement / trophy. Maximum Security is not that hard but you will notice less resources dropping from enemies.
Probably you will have to play again on NG+ to get all weapons and upgrades for Armed to the Teeth achievement / trophy.

3 and 4
Play the game in Hardcore Mode. In Hardcore Mode enemies are very tough and drop very little resources. Furthermore items have their price cut in half when you sell them so picking right upgrades will be the key here. See Contagion Mode Guide below.

5
Contagion Mode is similar to Hardcore run but game saves only the start of the chapter. Furthermore for You Belong Here achievement / trophy you can’t die at all. Or can you?
Check out the Contagion Mode chapter below.

6
Finish Final Transmission, get all collectibles and DLC achievements. Everything can be done during one run fortunately.

7. Riot Mode achievements. Everything can be done in one run. Getting to wave 50 is not hard but will take time, 1,5-2h of playing constantly. Be sure to check how to activate Rampage Mode which allow you to one shot any enemy. You must use it 10 times during the run for an achievement.

Grim Reaper – Harvest and read all implant bios

Information Overload – Find all 8 Protocol Data Drives

I Do Belong Here – Beat the game on any difficulty

The Protocol is About Life – Beat the game on Maximum Security difficulty

Recidivist – Finish Game in Hardcore Mode

Lifer – Finish Game in Hardcore Mode NG+

Glutton for Punishment – Finish Game in Contagion Mode

You Belong Here – Finish Game in Contagion Mode Without Dying

The Outer Way – Find the Outer Way boarding craft

Desperate Times – Elias gives Jacob a shiv

Paper Jams – Print a weapon for the first time

If the SHU Fits… – Activate the SHU

Without A Paddle – Survive the pipeslide

Crash Site – Return to the crashed ship

In the Pipe, Five by Five – Reach the Hangar flight deck

Power Up – Restore power to the old facility

Two Heads Are Better Than One – Take down the two-head

What Lies Beneath – Find the source

Full Circle – Get thrown back into original cell

Mugshot – Take a photo using photo mode

Flesh Wound – Use melee or ranged weapons to take both arms off a living enemy

This should unlock automatically as you fight your first enemy.
If for some reason it doesn’t wait till you get a gun and shoot off enemy arms.
You can also wait for NG+.

Float Like A Butterfly – Perfect dodge five times

This can be done as soon as you get your weapon or just after.
To make a Perfect Dodge you have to push the move button in last moment. Of successful you will get a slow motion dodge. To make it easier you can click spam the button instead of timing it.

The Commonality – Uncover the mystery of Kallipolis

For this one you have to find two secret rooms. One is in Chapter 3 and the second is in CHapter 6.

In Striking Distance – Kill an enemy via GRP and a melee combo

You will get GRP Glove in Chapter 3.
Just after that you will get attacked as part of a tutorial. You can get this achievement here.
You have to kill an enemy with a Stun Baton hit just after you throw him at the wall with GRP, so you will have to soften him up a bit before you use the GRP.

Workplace Hazard – Use GRP to kill an enemy by throwing them into an environmental hazard

Terminated – Take down a security robot

This can be done in Chapter 3. There will be a robot patrolling an area close to the end of the chapter.
Lower your difficulty to Minimum Security, hide behind a crate and wait for the robot. Hitting him 3 times in the head should be enough.
After achievement unlock get your difficulty back to where you want it and reload a checkpoint.

Armed to the Teeth – Purchase all weapons and upgrades

To get all weapons and upgrade them first you’ll have to find all schematics. Follow my all collectibles videos for that.
To upgrade everything you will have to finish New Game+ and probably half of another run on NG+. I got it somewhere in chapter 5 on my third playthrough.

Chew ‘Em Up – Kill ten enemies with environmental hazards

This should unlock naturally as you play through the game. Killing enemies by throwing them in hazards with GRP Glove is very efficient.

Get a Grip – Grab twenty-five enemies with the GRP

This should unlock naturally as you play through the game.

Giving Back – Stab five blind enemies in the back

In chapter 6 and 7 you will face new enemies – Blind Ones. They can’t see you and won’t be aggressive until you attack them or make some noise. It’s rather easy to backstab them and it’s the most efficient way to deal with them so this should unlock naturally.

Parole Denied – Finish New Game Plus Mode

Self explanatory 🙂

Reforged – Print a weapon upgrade

Self explanatory 🙂

You Need a Gun – Fully Upgrade One Weapon

Self explanatory 🙂

Glutton for Punishment – Finish Game in Contagion Mode

You Belong Here – Finish Game in Contagion Mode Without Dying

In Contagion Mode game saves only at the beginning of a chapter so if you die you will have to replay from this chapters start.
For You Belong Here I highly recommend doing save backups as soon as game saves. Also keep separate backups for each chapter just in case. If you die exit game, copy over the backup and load it. To be sure everything is alright check the time stamp of the save file you are loading. It works, that’s how I did it.

My upgrade strategy

Stun Baton – 3rd branch second upgrade ASAP to break through enemy block.
GRP Glove – 2 upgrades in energy capacity and 1 level of velocity and recharge time
Stun Baton – 1st branch, 2nd upgrade for increased damage
Hand Cannon – Magnum Bullets
Riot Gun – Magnum Bullets
GRP Glove – 2nd recharge time upgrade
Hand Cannon – secondary fire

Don’t bother with other weapons. You won’t have enough money to upgrade them and you will clog your inventory with extra ammo types.

It’s Time – Obtain the Kinetic Hammer

Story related and can’t be missed.

One Last Job – Finish Final Transmission

Story related and can’t be missed.

Information Overload – Find all 8 Protocol Data Drives

See All Collectibles section of this guide.

Don’t Let It Mellow – Destroy all Hammer Crates on the Factory Floor

At some point in the DLC you will get a Hammer that allow you to destroy yellow crates.
Follow this video to find them all.

Quick Pick – Solve any Security Lock System in less than 7 seconds

Go to options, Gameplay, Combat Assist and turn on QTE Single Press and QTE Auto Complete.

This Isn’t About Escape – Locate the Escape Pod

After you get the fuse from looped corridor you can open a door near the fuse box. Go towards the escape pod to unlock this one.

Keep Fighting – Killed your first Biobot!

Bear Trap – Kill a Two-Head with a Hazard

First Two-Head will spawn on wave 10.
You can buy a Fuse and activate a trap to get this achievement / trophy.

Big Game Hunter – Complete Wave 50

Big Spender – Spend 20,000 Credits

Should unlock naturally as you go for 50 waves.

Hoard Mode – Survive five consecutive waves without spending any Credits

You can get this in the first 5 waves or later once you have all upgrades you want.

I am the Danger – Dismember 100 limbs in Riot Mode

This will unlock automatically as you play through the Riot Mode

Instigator – Complete Riot Mode for the first time

Automatic unlock

Subject Alpha – Use the Power-up 10 times

Use Rampage Mode 10 times.